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Adegen
Prescription Strength
ARB Topical A5D is Adegen's foundational prescription-strength topical with dutasteride added for our strongest DHT defense. It combines 5% minoxidil and topical dutasteride with our proprietary ARB complex, plus tretinoin, caffeine, and a niacinamide + biotin blend to support absorption and overall follicle health.
Compounded in-house at Adegen Pharmacy and formulated to help key ingredients reach the follicle, where healthy hair growth begins, A5D addresses both growth support and maximum DHT defense in one formula.
About the Dutasteride in This Formula
Dutasteride inhibits both Type I and Type II enzymes responsible for converting testosterone to DHT in the scalp, for broader, stronger DHT reduction than finasteride, which blocks one. It's our most complete topical DHT defense, at any stage of hair loss.
Full Formulation
Best For Early to moderate thinning, and anyone who wants growth support and our strongest DHT defense in a single formula.
Safety & Rx Information This is a prescription-only compounded medication dispensed through Adegen Pharmacy, our licensed 503A compounding pharmacy. A licensed physician will review your information after checkout and determine if this formula is appropriate for you. Women who are pregnant or may become pregnant should not handle this product.
Apply 1 mL (10 sprays) to thinning or affected areas of the scalp once to twice daily, or as directed by your licensed physician. Each spray delivers approximately 0.1 mL (10 sprays = 1 mL). Gently massage in with one finger.
Microderm Scalp Roller
A precision scalp roller with surgical-grade stainless steel needles that create micro-channels to maximize absorption.
Exfoliation Brush
A precision scalp massage brush that stimulates circulation and exfoliates the scalp for better absorption.
Microderm Scalp Roller
A precision scalp roller with surgical-grade stainless steel needles that create micro-channels to maximize absorption.
Exfoliation Brush
A precision scalp massage brush that stimulates circulation and exfoliates the scalp for better absorption.
HOW IT WORKS
Everyday Regrowth
Extra Strength Regrowth
~70% DHT Reduction
~90% DHT Reduction
A scalp-first formula designed to support better delivery, healthier follicles, and stronger-looking hair.
Works at the scalp level to deliver active ingredients where hair growth begins.
Supports better delivery into the scalp so treatment can reach the follicle more effectively.
Helps support fuller-looking, healthier hair with consistent use over time.
Designed for simple daily use, making it easier to stay consistent and see progress.
“I tried everything before Adegen. Nothing worked—until now. I am so grateful to John and Adegen group for changing my life!”
"At day 49 I almost didn't take progress photos — I didn't think anything was happening. 11.5 months later, my hairdresser couldn't stop uncovering layers of new growth. I've never been happier about a bad hair day in my life."
“I couldn't be more ecstatic with the results. I have been using it for 5 months and I am seeing results that I never thought were possible. This has been a miracle solution, Adegen has been godsend to me, I'm so grateful!”
“I am happy with how healthy my hair is! Sometimes when I feel it isn't happening fast enough I have to go back to the day I was about to shave my head.”
“Honestly 3 months after using Adegen everything was completely different. May hairline started to fill up and my crown is filling like crazy. For the first time I am happy and confident on how my hair looks! I'm so gratful for this product”
“It’s not just my hairline that has gotten way better, but all of my hair is thicker and healthier than ever. These photos are only 6 months apart.Thank you Adegen!”
“It's been a little over 3 months of using the topical and under 3 months of using the shampoo and I'm pretty stocked about the results!”
“I was skeptical after trying everything on the market. After 3 months on Adegen, my hairline has visibly filled in. I finally feel confident again.”
Free from unnecessary fillers, heavy silicones, and harsh detergents. Every ingredient is chosen to support a healthier scalp environment and more effective follicle-level delivery.
ARB Proprietary Complex
A targeted complex designed to support the androgen receptor and follicle environment. By working at the follicle, it creates the foundation the rest of the formula builds on.
Micronized Minoxidil
Milled to under 10 microns for deeper scalp penetration and more effective follicle-level delivery. Smaller particles help the formula reach where regrowth support actually begins.
Tretinoin
Supports healthy scalp cell turnover while helping improve the absorption of key actives. It helps renew the scalp environment so the formula can work more effectively.
Caffeine
Helps support circulation around the follicle to improve the delivery of oxygen and nutrients. It also helps energize the scalp and support a healthier growth cycle.
Niacinamide + Biotin
A blend of nourishing B vitamins that support a balanced scalp and stronger-looking hair, reinforcing the environment healthy hair depends on.
Finasteride (add on)
Available as an Rx add-on, this topical active helps reduce DHT at the source by inhibiting 5-alpha reductase. Paired with ARB, it supports a more complete follicle-level approach to DHT management.
Dutasteride (add on)
Available as an Rx add-on, this more potent active helps reduce DHT by blocking both Type 1 and Type 2 conversion pathways. Combined with ARB, it offers the most comprehensive follicle-level DHT support in the lineup.
A side-by-side look at why Adegen stands apart, from formulation
ownership to follicle-level delivery.
100% in-house development by the team that pioneered the original 15% minoxidil formula.
ARB technology, DermalDrive™ delivery, and CryoSafe™ no-heat compounding.
USP Compendial Grade Dutasteride, Tretinoin, Micronized Minoxidil, Caffeine and more.
DermalDrive™ advanced delivery system engineered to drive micronized actives deep into the follicle.
Precision Applicator for fast, even, targeted scalp coverage. Complete System.
Compounded and shipped in-house for greater control over quality, consistency, and potency.
Generic third-party formulas with no direct formulation ownership.
Decades-old formulas with no innovation in formulation technology.
Commodity-grade actives at lower strengths with fewer performance-focused ingredients.
Standard solvents. Large particles that mostly sit on the surface.
Generic droppers: imprecise application, uneven scalp coverage, and product waste.
Outsourced to third-party pharmacies. Limited control over quality, consistency, and innovation.
100% in-house development by the team that pioneered the original 15% minoxidil formula.
Generic third-party formulas with no direct formulation ownership.
ARB technology, DermalDrive™ delivery, and CryoSafe™ no-heat compounding.
Decades-old formulas with no innovation in formulation technology.
USP Compendial Grade Dutasteride, Tretinoin, Micronized Minoxidil, Caffeine and more.
Commodity-grade actives at lower strengths with fewer performance-focused ingredients.
DermalDrive™ advanced delivery system engineered to drive micronized actives deep into the follicle.
Standard solvents. Large particles that mostly sit on the surface.
Precision Applicator for fast, even, targeted scalp coverage. Complete System.
Generic droppers: imprecise application, uneven scalp coverage, and product waste.
Compounded and shipped in-house for greater control over quality, consistency, and potency.
Outsourced to third-party pharmacies. Limited control over quality, consistency, and innovation.
Adegen starts working from day one, but visible results take time and consistency. Most people begin to notice changes around 90 days, and results continue to improve over the months and even years that follow.
Adegen is not a basic hair loss product. It is a prescription-grade system designed to target the key drivers of follicle weakening, including poor circulation, DHT activity, and inefficient follicular delivery. Powered by 15% micronized minoxidil, ARB technology, dutasteride, caffeine, tretinoin, and more, Adegen delivers a more comprehensive approach than conventional hair loss treatments.
Hair loss is an ongoing biological process, so maintaining results requires consistent care, much like diet, exercise, or oral health. Continued use of Adegen helps support circulation, follicle health, and the natural hair growth cycle, making it a simple part of your long-term hair maintenance routine.
A hair transplant moves existing follicles but doesn't stop the hair loss underneath, so results often fade without treating the root cause. That's why we recommend the full Adegen system first, usually three to six months. It strengthens your follicles for a better result with fewer grafts, and some people find they need fewer than planned, or no transplant at all. Watch John, who had a transplant himself, explain why.
Much of the fear around hair loss treatment online is louder than the evidence supports. Our topical system works at the scalp, and our oral options are prescription medications reviewed by a licensed physician who walks you through the real risks and benefits for your situation. Most people tolerate treatment well, and your physician can tailor your plan if any concerns come up. For men who want added peace of mind, we also offer daily tadalafil to support circulation and sexual health. Watch John break down what the research actually says.
Yes, and many do. Women's hair loss often traces to the same root cause as men's: restricted blood flow to the follicle. Many women see excellent results, and our HairIQ assessment builds a protocol suited specifically to them. We've helped women from their twenties into their eighties. Watch John explain why Adegen works so well for women.
