Why People Who Tried Minoxidil And Finasteride Are Switching To A New Treatment No Store Is Allowed To Sell
There's an unusual reason you've never seen this on a shelf. This protocol is what men and women turn to when no other hair loss treatment has worked.
If you used minoxidil exactly the way the box told you to and got nothing, or you were handed the pill and didn't want it, this is the part nobody explained to you.
I'm John Goss. I started losing my hair at twenty, used both approved drugs religiously, tried every shampoo and vitamin on the shelf, and paid for a transplant. I kept losing it anyway.
Here's what I found out about why, after twenty years of looking. I'll go through the three things almost everybody tries, what each one actually does, and the part none of them touch.
What Minoxidil Is Actually Doing Up There
Minoxidil came out of blood pressure research. Somebody noticed patients growing hair, and that observation became a hair loss drug. It's a vasodilator. It widens the vessel, more blood moves through it, and for plenty of people that's enough to notice something.
But look at where it acts. Minoxidil raises the pressure. It does nothing about what's restricting the flow.
It's like turning up the pressure on a garden hose without first removing the kink. It helps, but it doesn't address the underlying problem.
That's the first reason. There's a second, and it's why a lot of people got nothing at all.
Minoxidil in the bottle isn't the active drug. It's a precursor. Your scalp has to convert it, using an enzyme, before it does anything.
How much of that enzyme you have varies from person to person. If yours is low, you can apply minoxidil correctly, twice a day for two years, and be doing nothing except getting your hopes up on a schedule.
If that was you, it isn't a verdict on your hair. It's a verdict on the formulation.
I've been using minoxidil for well over 10 years, which slowed my hair loss, but didn't stop it. I started trying Adegen recently and can honestly say it has stopped my hair loss and I have regrown some hair. I likely won't get all of my hair back since it's been such a long time, but I've had people notice that my hair is now fuller.
The Pill Lowers DHT Everywhere. Including Where You Never Asked It To.
Finasteride is the other approved drug, and it acts on a different part of the problem. It lowers DHT, the hormone driving all of this. That's real, and for some people it's the right call.
Two things about it are worth knowing before you decide.
The first is where it works. It's a pill, so it lowers DHT everywhere in your body, not only at the follicles you're worried about. That's why the side effect conversation exists around it, and it's why a lot of people either won't start it or won't stay on it.
The second is what it still doesn't do. Lowering the signal doesn't restore what the signal already restricted, and it isn't a delivery mechanism for anything else.
You may be asking: so is the pill off the table?
No. It's an option a physician weighs with you, and some cases call for it. It just isn't the default here, and there's a full version of the protocol with no DHT blocker in it at all.
I Paid For The Surgery. I Kept Losing My Hair Anyway.
Somebody told me a transplant was the only real answer, so I had one.
And I kept losing my hair.
I want to be careful here, because transplants are real surgery done by real surgeons and the technique has come a long way. A transplant moves hair from where you still have it to where you don't. It was never designed to stop hair loss, and it does not. If the cause is still running underneath, you'll be back in that chair.
One customer wrote in that he'd just spent twelve thousand dollars on a transplant and wanted to keep what he had left. Another told us he was pricing flights to Istanbul before he found us.
The list of things that didn't work, in the order I tried them:
- Minoxidil and finasteride, the two approved drugs
- Every shampoo on the market
- Every hair vitamin
- Herbs imported from China
- A hair transplant
Years, real money, and a surgery. I was worse off than when I started, and the one thing nobody had ever given me was an explanation.
I have been using Adegen since October 2024. I've tried so many other treatments over the last 15 years. I have also seen at least 5 specialist who had no answers. … I have been very diligent with the Adegen protocol. It's so exciting to see the hair growth that I was told would never happen! Even my dermatologist said he sees a difference in my hair, and asked what I am using.
So What Is Actually Restricting Blood Flow To The Hair Follicle?
A hair follicle is a living organ. Small, but an organ. It runs on oxygen and nutrients, and those arrive one way: blood flow.
Androgen hormones convert to DHT. Both men and women have them. DHT binds to the androgen receptor at the hair follicle, and that binding disrupts the local blood supply.
An under-supplied follicle doesn't die dramatically. It shrinks. Each cycle it produces a slightly thinner, slightly weaker hair. That's miniaturization, and it's why thinning always comes before loss. By the time you can see it in the mirror, it's been running for years.
Thinning hair is not the problem. It's a symptom of the problem.
You may be asking: isn't this just genetics?
Partly. What runs in families is how sensitive your follicle receptors are to DHT. My own family tree told me exactly what was coming.
But sensitivity isn't the event. The event is DHT binding at the receptor and the blood supply dropping off behind it. Genetics loads the gun. The binding is what you can do something about.
Which changes what a treatment has to do. You don't force a follicle to grow. You take the restriction off and let it do what it's built to do. And nothing on a shelf takes the restriction off, because what does is prescription-only.
About 60 seconds. Free, no account, and a licensed physician reviews your case before anything ships.
Nobody Would Make The Formula, So We Spent Six Years Building The Pharmacy
I stopped shopping and started reading. NCBI, PubMed, journals, then the patent office. What I found buried in the literature were fatty acid complexes, linoleic and oleic acid, with studies pointing at the androgen receptor of the hair follicle. Not new, not exotic, and not for sale anywhere.
That bothered me more than anything else in twenty years of looking. Why would something studied and promising simply not exist as a product?
The answer turned out to be economics.
Anything marketed for hair loss in the United States has to go through drug approval. Drug approval costs a fortune. You only recover a fortune if you hold a patent. And you can't patent something natural, something already studied, or something already available as a prescription.
So the most interesting material in the literature is precisely the material nobody will ever fund.
Nobody's hiding this. There's just nobody whose job it is to tell you.
Between 2014 and 2020 I spent more than a million dollars of my own money traveling to chemists, formulators and manufacturers around the world. I sold my house. I sold my car. I cashed out my 401k.
Then I took the formula to compounding pharmacies. They couldn't make it, or they wouldn't. Different reasons, same answer.
So from 2020 to 2026 we built our own. Six years, bootstrapped, no outside investors, nobody to answer to. Today Adegen medications are compounded at Adegen Pharmacy, our own state-licensed facility here in the United States.
I want to be precise about why that matters, because it's easy to say and hard to do.
In this category it's normal for a brand to design a box, take the orders, and send the prescription to a pharmacy nobody there has ever set foot in. That's a supply arrangement, not a formulation. When you work that way, what your customer receives is whatever that pharmacy already makes.
We compound our own medications. It's the only reason the formula on this page exists in a bottle at all.
What's Actually In The Bottle
The topical carries ARB™, our complex of linoleic and oleic fatty acids. ARB binds the androgen receptor at the follicle, blocking DHT from attaching there, without lowering DHT anywhere else in your body. It isn't spurring growth. It's letting the follicle have a normal blood supply again.
That's the kink, removed.
With it: micronized minoxidil, milled under ten microns so it penetrates instead of sitting on the surface. Tretinoin, which supports the conversion problem from the first section and thins the outer layer of the scalp so more of what you apply gets through. Caffeine, adenosine and niacinamide for circulation and follicle condition.
The topical comes in two minoxidil strengths, 5% and 15%. Fifteen is three times the concentration of the standard 5% formulas on a shelf. The over-the-counter rules cap how much minoxidil a product can contain, and they don't allow it combined with the other actives in ours. A 15% formula with tretinoin in it can only exist as a prescription, compounded for one person.
Which strength you'd be on isn't something this page gets to decide. That's what the physician review is for, and stronger isn't automatically the right answer for everybody.
Then there's how you get any of it through skin built to keep things out.
The epidermis is a barrier. Think of an orange peel. Whatever you put on top of it, most of it stays on top of it. So the protocol is built backward from that fact. Three steps, and the order is the entire point.
Step one. Clear the path.
When people start thinning, the instinct is to be gentle with the scalp. It's the wrong instinct. You brush your teeth with a toothbrush, not your finger, because the job is removing what's built up. The scalp is the same. Dead skin, sebum, dandruff, and buildup all sit over the follicle openings.
ARB Shampoo+ goes on with the exfoliation brush, and it sits for five minutes instead of thirty seconds, because the actives need contact time to reach anything.
Step two. Open the door.
Down the road from where I live, they aerate the golf greens. A machine punches vertical holes in the turf, and then the fertilizer goes in. Not on top of it. Into it. That's the only reason it reaches the roots.
The Microderm Roller does that to the scalp. The needles are set individually at ninety degrees, which is what makes them puncture cleanly instead of tearing. Two things happen at once. You get micro-channels for the topical to travel through. And your body responds the way it responds to any small injury, by sending blood to the area. When you twist your ankle and it swells, that's blood arriving at damaged tissue. Here, that response is the point.
Step three. Deliver the formula.
This is the step that everything else exists to make possible.
The cleanse cleared the openings and the roller opened the channels. This is where the ARB topical goes in, straight onto the scalp, while those channels are still open.
Which of the three steps your case needs, and at what strength, isn't a guessing game. The assessment asks, then a licensed physician reviews it.
I Never Asked Anybody To Post Their Pictures
I started a Facebook group so people could compare notes with each other. I never asked anyone for a photo. They started posting before-and-afters anyway, then started answering each other's questions faster than we could.












Two of them have the Adegen logo tattooed on their bodies. People hide this. I did it for years, under a hat. Nobody advertises the hair product they're on, because most of the time it isn't working and they'd rather you didn't know they were trying at all.
More than 50,000 customers have used Adegen. That's nearly 100,000 orders, and close to 500,000 bottles, brushes and rollers. A lot of them arrived the way you did, at the end of a list of things that didn't work.
I'm going to let them talk, and I'm not editing out the doubts.
The story from the John and all the ways he tried and all the research he did made it more believable! I figured what the heck give it a try. Followed the instructions and by 6 months my front hair line if full of new hair and my two bald spots are completely covered with new hair. My hair stylists was so shocked that she has told many clients about adegen! My wife is like your hair now looks like it did 20 years ago!
I am a 73 year old male who has been dealing with my hair loss for 50 years. ugh. I have over the years tried EVERYTHING on the market including laser combs. Nada. Zilch. Zippo. I started Adegen about the 3rd of January 2021 and I am seeing AMAZING results.
It took about two months of really following the program to see my shedding almost stop and baby hairs start to grow. Since then it's gotten better and better.
The product works. With so many product promising results and not delivering this one pulled through for me. I consistently used the product daily. Shampoo w/ scalp massager allow to sit for 5 min. Every day. MWF used the roller. Then applied topical directly after drying hair and/or using roller. I'm 48m and it worked for me.
See what the protocol looks like for your pattern. Free, no account, and nothing is charged until a physician approves it.
What Actually Happens In The First Hundred Days
I'm going to set this expectation low on purpose, because I'd rather you be pleasantly surprised than quietly angry at me in four months.
Hair grows on a cycle. The growth phase runs roughly 90 to 100 days, and no formula skips it. That makes three months the honest minimum window for visible change, and months three through six the real test.
Day 1
Starting point. Follicles may be weakened by reduced circulation and DHT buildup, leading to thinning and slower growth.
Simeon, photographed by himself on the same schedule. One person's timeline, not a forecast of yours.
Some people shed more in the first few weeks. That's usually cycle turnover, follicles ending an old phase and starting a new one, which pushes old hairs out on the way. It's unnerving if nobody warns you. It's not the protocol failing.
The first thing most people notice isn't new hair. It's less hair where they normally count it. The drain. The pillow. The sink.
Day 100 can be underwhelming. Our own community says that to each other constantly, more bluntly than we'd ever say it in an ad.
Then there's the part that's on you, and I'm not going to soften it.
Don't buy this if you're just going to wing it and half-ass it.
If you're not going to do this most days for three months, the money is wasted and I'd rather you keep it. Consistency is the variable that decides the outcome. Every result on this page belongs to somebody who was boring about it.
I've been taken advantage of. I don't like it and I want to help people. The last thing I want to do is over-promise and under-deliver.
The product works. With so many product promising results and not delivering this one pulled through for me. I consistently used the product daily. Shampoo w/ scalp massager allow to sit for 5 min. Every day. MWF used the roller. Then applied topical directly after drying hair and/or using roller. I'm 48m and it worked for me.
It took about two months of really following the program to see my shedding almost stop and baby hairs start to grow. Since then it's gotten better and better.
How To Get Started With Your Personalized Hair Loss Treatment
Everything above is true of hair loss in general. None of it tells you which part is yours, and that's the question that decides what you should actually be on.
Whether your scalp converts minoxidil. How long yours has been moving. Where you're losing it, because a crown and a hairline don't behave the same way. What you already tried and what happened when you did. What you'd rather avoid entirely.
In more than twenty years, with a pharmacist for a mother and three doctors at the dinner table, not one licensed physician ever sat down, looked at my case, and told me what to do about it. I was handed a category and left to guess, the same as everybody else.
So we made that the front door.
HairIQ™ is the assessment I never got. It asks what your pattern is, how long it's been going, what you've already used and how that went, and what you'd rather not take. Then it weighs your answers against 160+ clinical decision rules and 25,000+ data point combinations and recommends the protocol your case points to.
Not everybody needs the whole kit, and the assessment will tell you plainly if that's your case. I'd rather sell you the right thing than the biggest thing.
You see your exact recommendation and its exact price on screen before you decide anything. Not a range, not a starting-at. Then a licensed physician reviews the case, screens it against your history and your medications, and either approves it or recommends a different formula.
It takes about 60 seconds. It's free, there's no account, and nothing is charged until a physician approves your treatment.
About 60 seconds. You see the recommendation and the exact price before you decide anything.
What This Actually Costs
What I've described is the Complete Regrowth Kit. It's the whole protocol in one box, and a 90-day kit is four pieces:
- ARB Shampoo+, for the cleanse and exfoliate step
- Your ARB topical, in the formula the physician approves
- The Microderm Roller
- Two Scalp Exfoliation Brushes
The unit I'd point you to is 90 days, because a hair cycle doesn't care about a monthly billing convention. You can start on a monthly plan instead, and plenty of people do.
Across everybody who's started since we moved to this model, the middle of the pack is $3 per day. Some pay less, because their case only calls for one piece of the protocol. Some pay more. What moves it is which formula a physician approves and how much of the protocol you actually need.
A few things worth knowing now, because they're usually what people find out afterward.
- The roller and both brushes come with the first kit at no extra cost. They ship once, they're yours, and they're not on the recurring order, because you don't need a new roller every quarter.
- The physician review is included. There's no separate consultation fee, and there isn't a version of this where you pay for the review and then pay again for the medication.
- Ninety-day orders ship free.
You're buying one protocol, not four products that were never designed to work together. That's what I was doing for twenty years, and it's the most expensive way to do this that I know of.
Not a range, not a starting-at. What yours actually costs, on screen, before you decide anything.
You're Not Charged Unless A Licensed Physician Approves Your Treatment
There's no money-back guarantee on this page, and I'd rather explain that than let you wonder about it. These are prescription medications compounded for one person. They can't be returned and dispensed to somebody else.
What we can do instead is make sure you never pay for something a physician hasn't approved.
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You take the assessment
You see the protocol your answers point to, with its price.
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You place the order
Your card is authorized. Nothing is charged yet.
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You complete a health questionnaire
About five minutes, online, no appointment.
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A licensed physician reviews your case
They screen it against your history and your medications, and either approve the order or recommend a different formula.
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If it's approved, it ships
The payment is captured and it ships from our US-based pharmacy. If it's not approved, the authorization is released and you pay nothing. There's no refund to chase, because there was never a charge.
Until a physician has looked at your case, the only thing you've spent is about a minute.
Adegen is LegitScript certified. LegitScript is an independent company that verifies telehealth providers and pharmacies. Google requires that certification before a company like ours can advertise at all. It isn't a government endorsement and it isn't an FDA approval. It means somebody outside this company checked who we are and what we dispense. You can look us up in their public directory.
About 60 seconds. Free, no account. Nothing is charged until a licensed physician approves your treatment.
Two Ways This Goes From Here
You can close this page. That's a real option, and for some people it's the right one.
Here's what that looks like, honestly, because I've lived it. Nothing happens today. Nothing happens this week. You check the pillow tomorrow morning the way you checked it this morning. Then in about a year somebody takes a photograph of you at an angle you didn't choose, and you do the math again.
That isn't me trying to frighten you. It's the direction this moves on its own. Every cycle the shaft comes back thinner than the one before, which means the head of hair you're deciding about today is the best one you'll be deciding about. A follicle responds best the earlier the restriction comes off.
Or you spend about a minute answering questions about your own head, and it stops being something you manage alone.
I'm not going to tell you what your hair is going to look like. I don't know, nobody does, and anyone who says otherwise is guessing at your expense.
What I can tell you is what changes the day you start. You stop shopping. You stop reading forum threads at midnight comparing what strangers did. There's a protocol, you follow it, and a licensed physician looks at your case before any of it ships. In three months you'll know something instead of wondering.
Whatever you tried before didn't fail because you didn't try hard enough. It failed because nobody ever told you what was restricting the follicle underneath.
About 60 seconds. Free, no account. You see everything, including the price, before you decide anything.
Questions People Ask Before They Start
No, and it's the question the most careful buyers ask first.
Minoxidil is in the formula and it earns its place. It's a vasodilator, so it raises blood flow to the follicle. What it doesn't do is address what's restricting that flow, which is DHT binding at the androgen receptor. That's what ARB is built for: a proprietary complex of linoleic and oleic fatty acids that blocks DHT at the receptor locally, without lowering DHT through your whole body. And because minoxidil only does anything after your scalp converts it, every Adegen topical includes tretinoin, which supports that conversion and improves penetration.
Minoxidil turns up the flow. ARB removes the restriction. Tretinoin makes sure the minoxidil you apply becomes the form that works.
Possibly because of the conversion step above. Minoxidil is inactive until an enzyme in your scalp converts it, and how much of that enzyme people have varies. If that was the reason, a formula built with tretinoin changes the conditions. That's not a promise about your case. It's a specific reason the last attempt may have failed, and it had nothing to do with your effort.
DHT doesn't stop being produced just because your hair came back, so keeping follicles in good condition is ongoing. If you stop entirely, the process that was running before will resume over time. That's the honest answer. What maintenance looks like once you have what you want is a conversation with the reviewing physician. That includes whether a lighter routine makes sense, and formula changes are part of the model.
Yes. The cause is the same, restriction at the follicle driven by DHT at the androgen receptor, though the pattern usually differs. Women more often describe a widening part and diffuse thinning rather than a receding hairline. Many women start on the version with no DHT blocker in it at all. The assessment routes for this, and the physician confirms what's appropriate.
Important: finasteride and dutasteride are not for women who are or may become pregnant. The physician confirms eligibility during the review.
Because of what's in it, not as a gate. Tretinoin is prescription-only, and it's in every topical variant because it does real work on absorption and on the minoxidil conversion problem. No over-the-counter product is permitted to combine multiple actives like this in one bottle. The prescription requirement is what allows the formula to be the formula.
Nothing is charged. Your card is authorized at checkout and captured only after approval. If the physician doesn't approve the order, the authorization is released and no charge is made. The outcome isn't always a flat no. The physician may recommend a different formula than the one you selected, and you can accept it or decline it.
The first 90-day kit is four pieces: ARB Shampoo+, your ARB topical, the Microderm Roller, and two Scalp Exfoliation Brushes. The roller and brushes ship once with the first kit and aren't part of the recurring order. After that, the shampoo and topical continue every 90 days at the same price. You can change your formula, skip a shipment, or cancel from your account, or by emailing our team. There's no contract.
The United States only. We don't ship internationally.
We can't ship any product to Alabama, Arkansas, Kentucky, Delaware, or South Carolina, or to US territories and military addresses. Massachusetts can receive oral medications, shampoo, and accessories, but not prescription topicals or the complete kit. Checkout will tell you before you get far.
About 60 seconds. Free, no account. Nothing is charged until a licensed physician approves your treatment.